osfr: An R Interface to the Open Science Framework
osfr provides an idiomatic R interface to OSF (Open Science Framework, https://www.osf.io), a free and open source web application that …
Adducins inhibit lung cancer cell migration through mechanisms involving regulation of cell-matrix adhesion and cadherin-11 expression
Cell migration is a critical mechanism controlling tissue morphogenesis, epithelial wound healing and tumor metastasis. Migrating cells …
Cross-species alcohol dependence-associated gene networks: Co-analysis of mouse brain gene expression and human genome-wide association data
Genome-wide association studies on alcohol dependence, by themselves, have yet to account for the estimated heritability of the …
Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems
BACKGROUND: Characterizing aggregate genetic risk for alcohol misuse and identifying variants involved in gene-by-environment (G × E) …
The allostatic impact of chronic ethanol on gene expression: A genetic analysis of chronic intermittent ethanol treatment in the BXD cohort
The transition from acute to chronic ethanol exposure leads to lasting behavioral and physiological changes such as increased …
The Rate of Change in Alcohol Misuse Across Adolescence is Heritable
BACKGROUND: Alcohol use typically begins during adolescence and escalates into young adulthood. This represents an important period for …
Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students
Background: Genetic factors impact alcohol use behaviors and these factors may become increasingly evident during emerging adulthood. …
Sphingosine-1-phosphate phosphatase 2 promotes disruption of mucosal integrity, and contributes to ulcerative colitis in mice and humans
The bioactive sphingolipid sphingosine-1-phosphate (S1P) and the kinase that produces it have been implicated in inflammatory bowel …
Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains
Genetic differences in acute behavioral responses to ethanol contribute to the susceptibility to alcohol use disorder and the reduction …
Time-Course Analysis of Brain Regional Expression Network Responses to Chronic Intermittent Ethanol and Withdrawal: Implications for Mechanisms Underlying Excessive Ethanol Consumption
Long lasting abusive consumption, dependence, and withdrawal are characteristic features of alcohol use disorders (AUD). …
Establishing an analytic pipeline for genome-wide DNA methylation
The need for research investigating DNA methylation (DNAm) in clinical studies has increased, leading to the evolution of new analytic …
Integrating Genomic and Genetic Data Across Species to Identify Gene Networks Contributing to Ethanol Behaviors and Alcohol Use Disorder
Mouse genomic studies on acute or chronic ethanol exposure models have been previously used to identify gene networks and cognate hub …
Incorporating Bioinformatics Data to Understand Alcohol-related GWAS Results
PURPOSE. Genome-wide association studies (GWAS) of alcohol dependence and genetically correlated externalizing disorders have produced …
Genomic influences on alcohol problems in a population-based sample of young adults
AIMS: Alcohol problems (AP) contribute substantially to the global disease burden. Twin and family studies suggest that AP are …
Biological insights from 108 schizophrenia-associated genetic loci
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small …
Integrating genomic and genetic data suggests circuit development abnormalities in schizophrenia
It seems likely that the genetic contribution of common variants to the risk of major psychiatric disorders is distributed across at …
Role of Adrenal Glucocorticoid Signaling in Prefrontal Cortex Gene Expression and Acute Behavioral Responses to Ethanol
BACKGROUND: Glucocorticoid hormones modulate acute and chronic behavioral and molecular responses to drugs of abuse including …
Genetic dissection of acute ethanol responsive gene networks in prefrontal cortex: functional and mechanistic implications
BACKGROUND: Individual differences in initial sensitivity to ethanol are strongly related to the heritable risk of alcoholism in …
Identifying Gene Networks Underlying the Neurobiology of Ethanol and Alcoholism
For complex disorders such as alcoholism, identifying the genes linked to these diseases and their specific roles is difficult. …
MicroRNA profiles in allograft tissues and paired urines associate with chronic allograft dysfunction with IF/TA
Despite the advances in immunosuppression, renal allograft attrition over time remains unabated due to chronic allograft dysfunction …
Urine miRNA panel as accurate biomarkers for monitoring kidney graft function
Background. Improvement in short term outcomes in kidney transplantation (Tx) had been achieved. However, long-term outcomes have not …
Using expression genetics to study the neurobiology of ethanol and alcoholism
Recent simultaneous progress in human and animal model genetics and the advent of microarray whole genome expression profiling have …
The benefits of human-companion animal interaction: a review
This article provides a review of research published since 1980 on the benefits of human-companion animal interaction. Studies focusing …